So I promised that list and here it is. It's late and it's not as thorough as I'd hoped. I also wish I had images handy to illustrate every point where helpful. So, in no particular order - a subjective set of desired features for Fallout 4:
Pay close attention to the direction that monsters are moving in so that you can plan your movements.
When you pick up a powerful weapon, use the opportunity to clear the screen of the more troublesome baddies.