So I promised that list and here it is. It's late and it's not as thorough as I'd hoped. I also wish I had images handy to illustrate every point where helpful. So, in no particular order - a subjective set of desired features for Fallout 4:
While the game tells you to play with headphones (true), it also neglects to tell you to play when you've got a decent chunk of time - you can't save during cutscenes.
Tap on everything on-screen and see what Brian says about it.