So I promised that list and here it is. It's late and it's not as thorough as I'd hoped. I also wish I had images handy to illustrate every point where helpful. So, in no particular order - a subjective set of desired features for Fallout 4:
Remember to make the lizards take the longest route you can when you put down your towers.
You can see the routes flying units take, so make sure they're covered.
Sometimes, it's worth upgrading old towers instead of buying new ones.