Update: I was unfortunately not aware of Shamus Young's severe criticism of Fallout 3 available here to link in the original piece and I regret that. It dovetails rather nicely with what I've written and it's much better executed than my piece. I strongly recommend anyone...
Keep an eye on Stubies getting stuck, for they can be troublesome.
You always get a chance to save a Stubie from the edge of the map, so look out for those wiggling arms.
You don't need to match bombs to bombs of the same colour.