So I promised that list and here it is. It's late and it's not as thorough as I'd hoped. I also wish I had images handy to illustrate every point where helpful. So, in no particular order - a subjective set of desired features for Fallout 4:
Work out how the gravity affects your jumps in the early stages so you know what to expect later on.
Check the map often in the Adventure mode to see where you've been.
Sometimes it's worth a sacrifice to get to the checkpoint.