Muscle at the front, magical brains at the back, and do whatever it takes to prevent enemies from getting too close to your squishier characters.
If one of your characters is getting further ahead in the XP stakes, let him take the backseat for a while, or leave him behind entirely.
You can't swap out items in your stash during combat, so make sure you don't wander into a scrap poorly equipped.
Here's how the Pinning system works in the game. If a monster is adjacent to one of your characters at the start of the turn, there's a chance they'll be Pinned. If that happens, they won't be able to move from their current position, but they can still take swings at the enemy involved.
For a melee party member to make a successful attack, they need to be in a square that's adjacent to an enemy.
Ranged fighters cannot be adjacent to a creature if they want to make an attack, so move them back a little if they need to find their necessary range.
Be sure to check the market thoroughly for any upgrades that could make your next adventure a good deal easier. You can buy potions, scrolls, weapons and armor in these town areas - don't forget to sell any trash items you've collected if you need a little more cash for your next major upgrade.