Update: I was unfortunately not aware of Shamus Young's severe criticism of Fallout 3 available here to link in the original piece and I regret that. It dovetails rather nicely with what I've written and it's much better executed than my piece. I strongly recommend anyone...
Enter the realm of a retired assassin, forced back into action by treason. You may be a hired killer but you still have a sense of loyalty and justice.
Visit the dark recesses of a world corrupted by crime, greed, degradation and dishonour. And a past that catches up with you.
Trust no one - if the price is right, the finger of your most trusted ally will be on the trigger.
Your targets may hide in the most remote areas of the planet, but their destruction is never prevented - only postponed.