It always helps to know where you're going at Comic-Con, especially if you don't want to stand in lines for too long and/or if you don't have many days to explore the floor. So here is a handy-dandy floor plan with red rectangles around where the video game booths will be this year, which are happen to be bunched up in the upper left-hand corner of the convention center. The other half of the map doesn't have much related to video games, other than Penny Arcade, but it can be found at the Comic-Con official site.
Also boxed are Nintendo, Namco Bandai, Penny Arcade, and Mega64, whose logos are not presented in the original map but are added here for emphasis.
Don't be surprised to find playable builds of Street Fighter X Tekken, and with any luck, the PS Vita, Uncharted 3, Assassin's Creed: Revelations, and of course Batman: Arkham City (line up for this immediately if it's there).
[Click image to enlarge.]