| A Good Dam Fight (25) | Defeat the Battlelord on the Hoover Dam | 
		
			| Air-Duke (30) | Win air hockey with a score of 7-0 in the strip club | 
		
			| Annihilation (40) | Kill 100 aliens | 
		
			| Balls of Steel (25) | Earn a 1,000,000 pinball score in SP | 
		
			| Baron von Nukem (20) | Shoot down 20 alien fighters | 
		
			| Beating the One-Eyed Worm (35) | Defeat the Energy Leech | 
		
			| Big Guns, Big Ships (10) | Blow up 5 enemy gunships or dropships | 
		
			| Bucket Head (30) | Find all 3 helmets in the SP campaign | 
		
			| Call Waiting (25) | Listen to all phone messages | 
		
			| Come Get Some (40) | Complete the SP campaign on Hard Difficulty | 
		
			| Companion Barrel (10) | Unlock the secret closet at the end of the Forkstop | 
		
			| Damn, I'm Good (50) | Complete the SP campaign on Insane Difficulty | 
		
			| Dead Useful (15) | Kill 10 aliens with environmental explosives | 
		
			| Downtown Barrel Beatdown (15) | Kill 10 aliens with tossed objects | 
		
			| Drawrings (10) | Doodle something on the whiteboard in SP | 
		
			| Duke Angry, Duke Smash! (20) | Kill 15 aliens with melee attacks while on steroids | 
		
			| Extermination (25) | Kill 50 aliens | 
		
			| FBT (10) | Get knocked down 10 times | 
		
			| Flagon of Chuckles (5) | Drink a beer in SP | 
		
			| Fork the Pork (10) | Kill 6 aliens with the forklift | 
		
			| Freeze Well! (20) | Kill 15 frozen aliens | 
		
			| Gunslinger (50) | Carry the gold pistol through the whole SP campaign | 
		
			| He's Got a Hologram! (5) | Use a Holoduke in SP | 
		
			| Hippy-Stomper (20) | Foot stomp 12 aliens | 
		
			| I Am All That Is Man (40) | Discover all Ego cap awards | 
		
			| I Need a Date (5) | Look at every page of a calendar in SP | 
		
			| I Need a Towel (10) | Get hit by 10 Pregnator bombs | 
		
			| Judge, Jury, Executioner (20) | Execute 20 aliens | 
		
			| Juiced (5) | Take steroids in SP | 
		
			| Let's Rock (30) | Complete the SP campaign on Normal Difficulty | 
		
			| Lots of Whacking (25) | Win a game of Alien Abortion in the strip club | 
		
			| Natural Disaster 3x (10) | Kill 3 aliens at once | 
		
			| Nobody Likes a Whiner (5) | Knock out the talent at the talk show | 
		
			| Noms (10) | Eat 10 pieces of food during the SP campaign | 
		
			| Not Bad for a Human (40) | Defeat the Alien Queen | 
		
			| Nuclear Devastation (50) | Kill 250 aliens | 
		
			| Octacide (25) | Defeat the Octaking | 
		
			| On the Noggin (25) | Kill 30 aliens with headshots | 
		
			| One-Eyed Freak (10) | Defeat the Cycloid | 
		
			| Party Animal (10) | Drink all of the beers in the strip club | 
		
			| Pescaphobe (10) | Kill all the catfish in the underwater level | 
		
			| Piece of Cake (20) | Complete the SP campaign on Easy Difficulty | 
		
			| Pit Champion (25) | Defeat the Battlelord in Las Vegas | 
		
			| Road Rage (20) | Kill 15 aliens with the monster truck | 
		
			| Special Thanks (5) | Watch the credits all the way through | 
		
			| Sticky Bomb Like You! (10) | Put a Trip Mine on a live alien | 
		
			| Substance Abuser (10) | Drink beer while on steroids or vice versa in SP | 
		
			| Sunday, Black Sunday (5) | Shoot down the blimp above the stadium | 
		
			| Trapper (20) | Kill 10 aliens with Trip Mines | 
		
			| Turd Burglar (10) | Find and steal a piece of poo |