Master of Orion
At any Planet screen, hold Alt and type moola.
Hold Alt and type galaxy in game play for the galaxy to be revealed.
Build a ship with a single MISSILE (NOT torpedoes or scatter packs) and one of the extras that knock out armor (i.e., Neutron Stream Projector). Make this ship FAST and TOUGH. In combat, turn off your missiles, move in close to the enemy ships (within 2 spaces). Fire your weapons at a group of ships, then click on WAIT. Pray that your ship(s) survive the counterattack (if any). If you survive, you get to go again. Trick is, your extra weapons are STILL AVAILABLE. Keep using the extra weapon, then click on wait, and fire, and wait, and fire, and wait. (You get the idea.) The enemy will have NO opportunity to return fire and will helplessly die.
Note: This glitch is only definite for the Mac; I have no information on it (one way or the other) for any other platform.
Thanks to Revolution readers Rod Hyatt, Spencer Sample and David J. Gannon!!