- Terminator 2 Reference - In the Foundry level, it's possible to fall into molten liquid and die. If that does happen, your character will give a thumbs up sign as he sinks into the soup, a reference to events depicted in the classic sci-fi film, Terminator 2.
- Skyrim Nod - Explore the Kadingir Sanctum, near where you first meet the Baron of Hell. There, you'll find a cave with a hidden lever and a skeleton. The skeleton is wearing the Dovahkiin horned helmet, and has an arrow in its knee, a reference to the popular meme.
- Demon Deconstruction - As you play through the "Lazarus Labs" mission, make your way to the room with the DOOM Guys crypt. Along the left side, you'll find a cabinet you can interact with to obtain the "Time Well Spent" challenge on the mission. The gameplay resembles Bejeweled.