To go anywhere instantly, click on the map. Hold Shift, S, and V then click twice on a location and let go.
The fastest way to get all 75 cards is to walk back and forth between Mr.Burns' office and the Reactor Core and collect the same cards.
Another way to get the 75 cards is by going to Krusty Studio and looking under the Law Of Labor paper, then go into a studio, go back out and look under it again - do this over and over again.
Thanks to Revolution readers Coolguy, Eden Trebilco, and Kevin Quillen!