The Letters of the Lost are the focus of Far Cry 3's Dead Letters Trophy/Achievement. To unlock this piece of digital showmanship, you just have to find all 20 letters and collect them. This is a lot simpler than it seems, especially when you consider that the collectible maps are available for purchase at the general stores.
If you're super cheap or some kind of horder, you can use the video above to find the Letters of the Lost and unlock the Dead Letters Trophy/Achievement.

Embark on an inspiring mission of human connection beyond the UCA. Sam — with companions by his side — sets out on a new journey to save humanity from extinction. Join them as they traverse a world beset by otherworldly enemies, obstacles and a haunting question: should we have connected?