Here are all the Panic Room locations for the Old Town Region in Dead Rising 4, denoted by the purple squares. You'll find their detailed locations below the images.
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1. McKenzie Auto - Back room on the floor, switch exposed on the wall.
2. Cochrane's Irish Pub - Basement on the right wall in between posters.
3. B. Reddy Insurance - Second floor (alleyway dumpster access), in the large room behind a bookshelf.
4. Apartment Above Dodds Drugs - Alleyway dumpster access - behind the bookshelf in the hallway next to the kitchen.
5. Willamette Gazette - Immediately to the right before the back door.
6. Willamette City Hall Archives - In a room past the files (night vision lens maybe required to get there), on the floor, switch exposed on the wall.
7. Willamette Bus Depot - Left wall behind the counter.